Don't miss reading this link on the topic of GERD and melatonin

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http://www.medscape.com/viewarticle/717460

Note how effective melatonin is for GERD when compared
to PPI meds.

And remember the list of adverse effect caused by PPI meds
while thinking about the above.

[Tim]

I object to the last line.

BMC Gastroenterol. 2010 Jan 18;10:7.

The potential therapeutic effect of melatonin in Gastro-Esophageal
Reflux Disease.
Kandil TS, Mousa AA, El-Gendy AA, Abbas AM.

Gastro-Enterology Surgical Center, Faculty of Medicine, Mansoura
University, Mansoura, Egypt. ***@mans.edu.eg

BACKGROUND: Gastro-Esophageal Reflux Disease (GERD) defined as a
condition that develops when the reflux of stomach contents causes
troublesome symptoms and/or complications. Many drugs are used for the
treatment of GERD such as omeprazole (a proton pump inhibitor) which
is a widely used antiulcer drug demonstrated to protect against
esophageal mucosal injury. Melatonin has been found to protect the
gastrointestinal mucosa from oxidative damage caused by reactive
oxygen species in different experimental ulcer models. The aim of this
study is to evaluate the role of exogenous melatonin in the treatment
of reflux disease in humans either alone or in combination with
omeprazole therapy. METHODS: 36 persons were divided into 4 groups
(control subjects, patients with reflux disease treated with melatonin
alone, omeprazole alone and a combination of melatonin and omeprazole
for 4 and 8 weeks) Each group consisted of 9 persons. Persons were
subjected to thorough history taking, clinical examination, and
investigations including laboratory, endoscopic, record of esophageal
motility, pH-metry, basal acid output and serum gastrin. RESULTS:
Melatonin has a role in the improvement of Gastro-esophageal reflux
disease when used alone or in combination with omeprazole. Meanwhile,
omeprazole alone is better used in the treatment of GERD than
melatonin alone. CONCLUSION: The present study showed that oral
melatonin is a promising therapeutic agent for the treatment of GERD.
It is an effective line of treatment in relieving epigastric pain and
heartburn. However, further studies are required to confirm the
efficacy and long-term safety of melatonin before being recommended
for routine clinical use. TRIAL REGISTRATION: QA13NCT00915616.

PMID: 20082715 [PubMed - in process]

[Taka]

All looks so good for melatonin, potent inhibitor of lipid
peroxidation and rejuvenating hormone of youth. Simply cut the
artificial lights in the evenings and you will be GERD free ...

Taka

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Post by Tim
I object to the last line.
BMC Gastroenterol. 2010 Jan 18;10:7.
The potential therapeutic effect of melatonin in Gastro-Esophageal
Reflux Disease.
Kandil TS, Mousa AA, El-Gendy AA, Abbas AM.
Gastro-Enterology Surgical Center, Faculty of Medicine, Mansoura
BACKGROUND: Gastro-Esophageal Reflux Disease (GERD) defined as a
condition that develops when the reflux of stomach contents causes
troublesome symptoms and/or complications. Many drugs are used for the
treatment of GERD such as omeprazole (a proton pump inhibitor) which
is a widely used antiulcer drug demonstrated to protect against
esophageal mucosal injury. Melatonin has been found to protect the
gastrointestinal mucosa from oxidative damage caused by reactive
oxygen species in different experimental ulcer models. The aim of this
study is to evaluate the role of exogenous melatonin in the treatment
of reflux disease in humans either alone or in combination with
omeprazole therapy. METHODS: 36 persons were divided into 4 groups
(control subjects, patients with reflux disease treated with melatonin
alone, omeprazole alone and a combination of melatonin and omeprazole
for 4 and 8 weeks) Each group consisted of 9 persons. Persons were
subjected to thorough history taking, clinical examination, and
investigations including laboratory, endoscopic, record of esophageal
Melatonin has a role in the improvement of Gastro-esophageal reflux
disease when used alone or in combination with omeprazole. Meanwhile,
omeprazole alone is better used in the treatment of GERD than
melatonin alone. CONCLUSION: The present study showed that oral
melatonin is a promising therapeutic agent for the treatment of GERD.
It is an effective line of treatment in relieving epigastric pain and
heartburn. However, further studies are required to confirm the
efficacy and long-term safety of melatonin before being recommended
for routine clinical use. TRIAL REGISTRATION: QA13NCT00915616.
PMID: 20082715 [PubMed - in process]

I do as well when compared to conventional meds which
have a lengthy list of known risks. But this the standard
positon of most conventional researchers. Indeed, I
suspect PPI meds adversely effect GI tract motility such
conventional Doc end up adding a motility med on top of
the PPI med.