There is mounting evidence that PPIs are associated with serious adverse effects. No matter the drug rep claimed this to be a low risk drug class, LOL

[PPI meds are toxic with time and dose]

1. Expert Rev Clin Pharmacol. 2013 Jul;6(4):443-51. doi:
10.1586/17512433.2013.811206.

Perils and pitfalls of long-term effects of proton pump inhibitors.

Wilhelm SM, Rjater RG, Kale-Pradhan PB.

Author information:
Department of Pharmacy Practice,
Eugene Applebaum College of Pharmacy and Health
Sciences, Wayne State University,
Detroit, MI, USA.

This review summarizes the literature regarding long-term adverse
effects of proton pump inhibitors (PPIs). A PubMed search
(1966 to February 2013) for English language studies was
conducted using key terms PPI: omeprazole, esomeprazole,
pantoprazole, lansoprazole, dexlansoprazole, rabeprazole,
pneumonia, Clostridium difficile, osteoporosis, risk of
fractures, thrombocytopenia, rhabdomyolysis, anemia,
iron deficiency, hypomagnesemia, vitamin B₁₂ and nephritis.
The risk of pneumonia was increased 27-39% in short-term
use of PPIs in three meta-analyses. C. difficile infections
were also associated with the use of PPIs
(odds ratio: 2.15; 95% CI: 1.81-2.55; p < 0.00001).
This effect appears to be dose related. The US FDA has
recently issued a warning regarding fractures and the
impaired magnesium absorption associated with the use of PPI.
Thrombocytopenia, iron deficiency, vitamin B12
deficiency, rhabdomyolysis and acute interstitial
nephritis have also been reported with the use of
PPIs. There is mounting evidence that PPIs are associated
with serious adverse effects. Practitioners should be
vigilant and counsel patients
accordingly.

PMID: 23927671

[Derek F]

Post by PPI meds are toxic with time and dose
10.1586/17512433.2013.811206.
Perils and pitfalls of long-term effects of proton pump inhibitors.
Wilhelm SM, Rjater RG, Kale-Pradhan PB.
Department of Pharmacy Practice,
Eugene Applebaum College of Pharmacy and Health
Sciences, Wayne State University,
Detroit, MI, USA.
This review summarizes the literature regarding long-term adverse
effects of proton pump inhibitors (PPIs). A PubMed search
(1966 to February 2013) for English language studies was
conducted using key terms PPI: omeprazole, esomeprazole,
pantoprazole, lansoprazole, dexlansoprazole, rabeprazole,
pneumonia, Clostridium difficile, osteoporosis, risk of
fractures, thrombocytopenia, rhabdomyolysis, anemia,
iron deficiency, hypomagnesemia, vitamin B₁₂ and nephritis.
The risk of pneumonia was increased 27-39% in short-term
use of PPIs in three meta-analyses. C. difficile infections
were also associated with the use of PPIs
(odds ratio: 2.15; 95% CI: 1.81-2.55; p < 0.00001).
This effect appears to be dose related. The US FDA has
recently issued a warning regarding fractures and the
impaired magnesium absorption associated with the use of PPI.
Thrombocytopenia, iron deficiency, vitamin B12
deficiency, rhabdomyolysis and acute interstitial
nephritis have also been reported with the use of
PPIs. There is mounting evidence that PPIs are associated
with serious adverse effects. Practitioners should be
vigilant and counsel patients
accordingly.
PMID: 23927671

I've been taking various ones since 2001. For the past ten years it has
been Esomeprazole that I have found to be the most effective. A doctor I
had said that he started taking them as soon as they came on to the market.
Derek

[PPI meds are toxic with time and dose]

Post by Derek F

Post by PPI meds are toxic with time and dose
10.1586/17512433.2013.811206.
Perils and pitfalls of long-term effects of proton pump inhibitors.
Wilhelm SM, Rjater RG, Kale-Pradhan PB.
Department of Pharmacy Practice,
Eugene Applebaum College of Pharmacy and Health
Sciences, Wayne State University,
Detroit, MI, USA.
This review summarizes the literature regarding long-term adverse
effects of proton pump inhibitors (PPIs). A PubMed search
(1966 to February 2013) for English language studies was
conducted using key terms PPI: omeprazole, esomeprazole,
pantoprazole, lansoprazole, dexlansoprazole, rabeprazole,
pneumonia, Clostridium difficile, osteoporosis, risk of
fractures, thrombocytopenia, rhabdomyolysis, anemia,
iron deficiency, hypomagnesemia, vitamin B₁₂ and nephritis.
The risk of pneumonia was increased 27-39% in short-term
use of PPIs in three meta-analyses. C. difficile infections
were also associated with the use of PPIs
(odds ratio: 2.15; 95% CI: 1.81-2.55; p < 0.00001).
This effect appears to be dose related. The US FDA has
recently issued a warning regarding fractures and the
impaired magnesium absorption associated with the use of PPI.
Thrombocytopenia, iron deficiency, vitamin B12
deficiency, rhabdomyolysis and acute interstitial
nephritis have also been reported with the use of
PPIs. There is mounting evidence that PPIs are associated
with serious adverse effects. Practitioners should be
vigilant and counsel patients
accordingly.
PMID: 23927671

I've been taking various ones since 2001. For the past ten years it has
been Esomeprazole that I have found to be the most effective. A doctor I
had said that he started taking them as soon as they came on to the market.
Derek

I'd urge you to get a second opinion from an alternative medicine provider.
When I took this drug class (omeprazole, rabeprazole), it controlled the "heartburn" more or less but it resulted in serious adverse effects. Plus, it impairs nutrient absorption as well.
Read my postings in archive. Many of them refer to the medical lit. I provide Pubmed ID numbers (PMID) with some of the stuff I post. If you're a completely conventional person just ignore me because even though much of what I say is in the "box", what helped me was outside of the mainstream /the "box".

Compare the similarity of melatonin and the various molecular structures of these copy-cat drugs in the PPI drug class.

Sorry you have the problem, the drugs won't fix it but only mask it and treat the symptoms. What helped me to get off the drug was the use of betaine HCL to increase stomach acidity to improve stomach motility and sphincter closure. A big proponent of this therapy was Jonathan Wright, he'd be retired by now, I suppose though his clinic may still be around in Washington State. YMMV.

Not medical advice in the final sense. You'll do what you do. What I say only makes conventional people sneer.

YMMV..................Trig
Best Wishes.....................Trig